Abstract Search

ea0081ep879 | Reproductive and Developmental Endocrinology | ECE2022

Daytime salivary androgen rhythm by LC-MS/MS in women affected by Polycystic Ovary Syndrome (PCOS) fulfilling the three Rotterdam diagnostic criteria

Fanelli Flaminia , Hawley James M , Mezzullo Marco , Fazzini Alessia , Zanotti Laura , Magagnoli Matteo , Pagotto Uberto , Keevil Brian , Gambineri Alessandra

Background: Excess testosterone in PCOS is accompanied by increased levels of other ovarian and adrenal androgens and precursors. Recently, 11-oxygenated adrenal androgens have been postulated as major components of the circulating androgen pool in PCOS. Obesity is strictly connected with androgen excess and with the derangement of hormone circadian rhythmicity. To date, it has not been clarified whether hyperandrogenism in PCOS, either complicated by obesity or not, is accomp...

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ea0029oc12.1 | Obesity Clinical | ICEECE2012

Circulating endocannabinoids are associated to cardiometabolic alterations independently from adiposity

Fanelli F. , Mezzullo M. , Belluomo I. , Di Lallo V. , Colavita M. , Baccini M. , Casadio E. , Ibarra Gasparini D. , Vicennati V. , Pasquali R. , Pagotto U.

Obesity is characterized by an increase of endocannabinoid circulating levels as anandamide (AEA) and 2-arachidonoyl-glycerol (2AG). Whether these lipids represent a biomarker of dysmetabolism or merely reflect the fat mass spill-over is still unclear. After generating rigorous, gender specific, plasma reference intervals by 2D-liquid chromatography-tandem mass spectrometry, we defined the 97.5thcentile of endocannabinoid distribution in the normal population as the cut-off ab...

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Endocrine Abstracts

Daytime salivary androgen rhythm by LC-MS/MS in women affected by Polycystic Ovary Syndrome (PCOS) fulfilling the three Rotterdam diagnostic criteria

Circulating endocannabinoids are associated to cardiometabolic alterations independently from adiposity

BiosciAbstracts